Total Herb Solutions USA / America Ayurvedic pre clinical, Ayurveda pre clinical, Botanical pre clinical, Plant Extract pre clinical
standardization of dietary supplements, Plant Extract pre clinical, Botanical pre clinical, Ayurveda pre clinical, Ayurvedic pre clinical

Preclinical Services

THS preclinical team works with clients to choose the most appropriate study design and screening method for an investigational agent and supports planning, performance and analysis of preclinical studies. Overview of our processes:

  • Pre-Trial Consulting
  • Feasibility Evaluation
  • Study Design & Protocol
  • Study Set-Up & Audits
  • Experimental & Project Management
We offer customized preclinical contract research services to Pharma and Biotech companies for drug discovery and development.
Our business strategy and commitment to quality has played a major role in the success of the following preclinical service areas:

Consultancy : THS is one-stop, complete range of accurate, reliable testing and consultation, we offer customized preclinical contract research services to pharma and biotech companies for drug discovery and development.

Our Strengths :
  • Integrated Preclinical development plan for NCE & NBE and timeline for successful clinical development and regulatory submissions
  • Experienced, highly trained Investigators (GLP)
  • Strategic and Operational Efficiencies
  • Rapid report preparation
  • High quality reports
  • Complete and comprehensive documentation
Ayurveda pre clinical, Herbal clinical studies,Herbal preclinical
Botanical pre clinical, Dietary supplement preclinical, Dietary supplement clinical studies
Nutraceutical preclinical, Nutraceutical clinical Studies, Plant Extract pre clinical

Toxicology : Non-GLP toxicology studies are intended to provide preliminary assessment of a drug's safety. Non-GLP toxicology studies can be performed on research grade materials to reduce costs and promote study design flexibility. These early stage studies can be performed prior to committing to the substantial costs in time and financial resources required to producing GMP grade material.

GLP toxicology studies are required as a prerequisite for filing an IND package and are normally performed only on GMP produced material prior to phase-I clinical trials. GLP-compliant regulatory tests are mandated for marketing approval. Toxicity Studies available include:

  • Single Dose Range Finding and Acute Toxicity Studies
  • Repeated Dose (28/90/180) Toxicology Studies
  • Carcinogenicity
  • Systemic and Local Toxicology
  • LD-50 and Maximum Tolerated Dose (MTD) Determination.
  • Genotoxicity (Invitro & Invivo Mutagenicity)
  • Male & Female Fertility Studies
  • PK/PD, ADME (I.V./Bolus, Abs.B.A)
  • Prenatal Development (2 generation)
Safety Efficacy :
Efficacy Studies :
  • In-vivo Diabetes
  • In-vivo Anti-inflammatory
  • In-vivo Adaptogenic
  • In-vivo Immunomodulatory
  • In-vivo Drug Interaction
  • In-vivo Aphrodisiac
  • In-vivo Antiulcer
  • In-vivo Cholesterol lowering
  • In-vivo Anticancer
  • In-vivo Antioxidant
Drug Metabolism and Pharmacokinetic Services:
  • Permeability (Caco2, MDCK)
  • CYP Mediated Metabolism
  • Protein Binding
  • Microsomal Metabolic Stability
  • PK & Routs of Excretion
  • 14C Studies (Mass Balance)

Safety Pharmacology (ICH-S7A) :
Core Battery
  CNS - G. Behavior
  • Motor Coordination
  • Locomotor
  • Exploration
CVS - Blood Pressure
  • Heart Rate
  • ECG (QT-Interval)
Respiratory- Tidal Volume
  • Respiratory Rate
  • Minute Volume
Follow Up and Supplemental Study

Serving Customers Globally

Total Herb Solutions Private Limited - India
Total Herb Solutions USA / America - Brazil,Spain,Greece,France,Finland,Germany,Gibralter,Italy,Ireland,Poland,Portugal,Spain
Total Herb Solutions UK / Europe - North America - Mexico,Panama,Cuba,Canada

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THS CENTER - Total Herb Solutions :

Herbal training, Herbs manufacturer,Indian medicinal herbs, Nutraceutical research, Nutritional label


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